This page provides insights into the capability of the Personalized Brain (PB) technology for analyzing brain information. Please note that the PB is still in development, and a comprehensive analysis will be provided in the future.
We used three datasets: T1-MRI mapping and fMRI mapping for three subjects— one with Alzheimer’s Disease (AD), one with Mild Cognitive Impairment (MCI), and one Normal Control Subject (NCS). Since we focused on fMRI mapping, our analysis only considers short-range connectivity between neurons while excluding long connectivity and high-frequency neural activities.
In the initial stage, we constructed the PB’s structure based on T1-weighted mapping. Subsequently, we utilized fMRI mapping to obtain short-range functional connectivity within the PB.
For our analysis, we conducted in vivo simulations by briefly stimulating the cingulate gyrus in PB while keeping the rest of the brain silent. We recorded the response to observe how functional activity spreads across the brain in the following moments. The figure below illustrates the average functional activity in PB during this test. The figure displays a horizontal slice of PB, and you can select different slices using the slide bar at the bottom.
To deepen our understanding, we calculated the response of different parts of PB to cingulate gyrus stimulation. The following figure demonstrates the synchronization of neural activity in other PB regions in relation to the cingulate gyrus. This figure presents data for the three subjects: AD, MCI, and NCS. The figure is interactive, allowing you to toggle the results for AD, NCS, and MCI subjects on or off.